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Tekstvak: Ms. Alma Groot-de Jong LABOKLIN GmbH Dorpsweg 13 Steubenstraße 4 1711 RD Hensbroek 97668 Bad Kissingen Niederlande Tel-Nr.: 0971-72020 date of arrival: 20-10-2010 ­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­ ­ patient identification:dog White Swiss Shepherd ­ male * 19.02.09 ­ date sample was taken: 18-10-2010 ­ owner /animal ID: Groot-de Jong, Alma ­ type of sample: swab ­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­ sample ID: 1010-S-17732 parameter value reference value Name: "Avathar Lothian Kann Schimmelpfeng" MDR1 genetic test - PCR MDR1-defect Result: genotype N/N (+/+) Interpretation: The analysed dog is a noncarrier of the mutation in the MDR1-gene that has been shown to cause hypersensitivity towards certain drugs such as ivermectin. The dog is free of the ivermectin hypersensitivity caused by this mutation. This mutation in the MDR1- gene was found in the following breeds: Collie, Shetland Shepdog, Australian Shepherd, Bobtail, Longhaired Whippet, Silken Windhound American White Shepherd, German Shepherd, Mc Nab, Wäller. This result is only valid for the submitted sample material and the dog breeds mentioned above. The DNA-test is run according to the publication of Mealey et al. (2001) "Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene." and detects the mutation MDR1 nt230 (del4). Name: --- pedigree-id: NHSB 2774307 chip-id: 963007000009434 tatoo-id: --- MDR1 genetic test carried out according to DIN EN ISO/IEC 17025 in our partnerlaboratory. Liability for specification of samples (e.g. name, identity of animal) lies by the sender. Tekstvak: V o o r b e e l d Tekstvak: V o o r b e e l d Tekstvak: V o o r b e e l d Tekstvak: V o o r b e e l d Tekstvak: Ms. Alma Groot-de Jong LABOKLIN GmbH Dorpsweg 13 Steubenstraße 4 1711 RD Hensbroek 97668 Bad Kissingen Niederlande Tel-Nr.: 0971-72020 date of arrival: 20-10-2010 ­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­ ­ patient identification:dog White Swiss Shepherd ­ ­ male * 19.02.09 ­ ­ date sample was taken: 18-10-2010 ­ ­ owner /animal ID: Groot-de Jong, Alma ­ ­ type of sample: swab ­ ­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­ sample ID: 1103-S-83393 parameter value reference value re-order 18.03.11 to result-no. 1010-S-17732 Name: "Avathar Lothian Kann Schimmelpfeng" Degenerative Myelopathy - PCR Result Myelopathy Result: Genotype: N/N Interpretation: The dog is homozygous normal concerning the intact SOD1-gene. The dog does not carry the mutation in SOD1 that is suggested to be a major risk factor for the development of Degenerative Myelopathy. The dog can pass only the normal gene on to all its offspring. The currently known mutation has been analysed. The result is only valid for the submitted sample. pedigree-id: NHSB 2774307 chip-id: 963007000009434 tatoo-id: --- Tekstvak: V o o r b e e l d